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| Cat.No | ACP12428 | Target Name | ACO2 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 28-780 | Protein Length | Full Length of Mature Protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q99798 |
|---|
Uniprot Id
Q99798
Target Species
Human
Target Name
ACO2
Target Full Name
Aconitate hydratase, mitochondrial
Target Function
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
Target Involvement
Infantile cerebellar-retinal degeneration (ICRD); Optic atrophy 9 (OPA9)
Target Subcellular Location
Mitochondrion.
Target Protein Families
Aconitase/IPM isomerase family
Target Research Area
Metabolism
Target Synonyms
ACO 2; ACO2; ACON_HUMAN; aconitase 2; Aconitase 2 mitochondrial; Aconitase; Aconitase2; Aconitate hydratase; Aconitate hydratase mitochondrial; ACONM; Citrate hydro lyase; Citrate hydro-lyase; ICRD; mitochondrial
Target Background
The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification.
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