Recombinant Human Activity-dependent neuroprotector homeobox protein (ADNP), Truncated

Uniprot Id

Q9H2P0

Target Species

Human

Target Name

ADNP

Target Full Name

Activity-dependent neuroprotector homeobox protein

Target Function

Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation.

Target Involvement

Helsmoortel-van der Aa syndrome (HVDAS)

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Widely expressed. Strong expression in heart, skeletal muscle, kidney and placenta. In brain, expression is stronger in the cerebellum and cortex regions. No expression detected in the colon. Strong increase of expression in colon and breast cancer tissue

Target Synonyms

Activity dependent neuroprotective protein; Activity dependent neuroprotector ; Activity-dependent neuroprotective protein; Activity-dependent neuroprotector homeobox protein; Adnp; ADNP_HUMAN; KIAA0784

Target Background

Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described.