Recombinant Human Adenylate cyclase type 3 (ADCY3) , Truncated

Uniprot Id

O60266

Target Species

Human

Target Name

ADCY3

Target Full Name

Adenylate cyclase type 3

Target Function

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Cytoplasm. Cell projection, cilium. Golgi apparatus.

Target Protein Families

Adenylyl cyclase class-4/guanylyl cyclase family

Target Tissue Specificity

Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level). Expressed in brain, heart, kidney, liver, lung, pancreas islets, placenta, and skeletal muscle. Detected in testis.

Target Research Area

Cancer

Target Synonyms

AC-III; AC3; ADCY3; ADCY3_HUMAN; adenylate cyclase 3; Adenylate cyclase; Adenylate cyclase type 3; Adenylate cyclase type III; Adenylyl cyclase 3; ATP pyrophosphate lyase; ATP pyrophosphate-lyase 3; olfactive type

Target Background

This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Two transcript variants encoding different isoforms have been found for this gene.