Recombinant Human Alkaline phosphatase, placental type (ALPP), Truncated

Uniprot Id

P05187

Target Species

Human

Target Name

ALPP

Target Full Name

Alkaline phosphatase, placental type

Target Function

Alkaline phosphatase that can hydrolyze various phosphate compounds.

Target Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor.

Target Protein Families

Alkaline phosphatase family

Target Tissue Specificity

Detected in placenta (at protein level).

Target Research Area

Tags & Cell Markers

Target Synonyms

ALPP; PLAP; Alkaline phosphatase, placental type; Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1; PLAP-1

Target Background

The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. One of the main sources of this enzyme is the liver, and thus, it's one of several indicators of liver injury in different clinical conditions. In pregnant women, this protein is primarily expressed in placental and endometrial tissue, however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells.