Recombinant Human Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (MGAT4C), Truncated

Uniprot Id

Q9UBM8

Target Species

Human

Target Name

MGAT4C

Target Full Name

Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

Target Function

Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity).

Target Subcellular Location

Golgi apparatus membrane; Single-pass type II membrane protein.

Target Protein Families

Glycosyltransferase 54 family

Target Tissue Specificity

Expressed in heart, adrenal gland, testis, liver, brain and fetal brain. Not expressed in pancreas.

Target Synonyms

MGAT4CAlpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C; EC 2.4.1.145; N-acetylglucosaminyltransferase IV homolog; hGnT-IV-H; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc; GlcNAc-T IVc; GnT-IVc; N-acetylglucosaminyltransferase IVc; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc

Target Background

Predicted to enable acetylglucosaminyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to be located in Golgi membrane.