Recombinant Human Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 (ST6GALNAC5), Truncated

Uniprot Id

Q9BVH7

Target Species

Human

Target Name

ST6GALNAC5

Target Full Name

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5

Target Function

Predominantly catalyzes the biosynthesis of ganglioside GD1alpha from GM1b in the brain, by transferring the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of GM1b. GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis. Also shows activity towards sialyl Lc4Cer (N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine) generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen.

Target Subcellular Location

Golgi apparatus membrane; Single-pass type II membrane protein.

Target Protein Families

Glycosyltransferase 29 family

Target Synonyms

6-sialyltransferase 5; 6-sialyltransferase V; Alpha N acetylgalactosaminide alpha 2,6 sialyltransferase 5; Alpha-N-acetylgalactosaminide alpha-2; GalNAc alpha 2,6 sialyltransferase V; GalNAc alpha-2; GD1 alpha synthase; SIA7E_HUMAN; Sialyltransferase 7E; Sialyltransferase E; SIAT7 E; SIAT7-E; SIAT7E; ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc V; St6galnac5; ST6GalNAcV

Target Background

The protein encoded by this gene is a Golgi type II transmembrane glycosyltransferase. The encoded protein catalyzes the transfer of sialic acid to cell surface proteins to modulate cell-cell interactions. Several transcript variants encoding different isoforms have been found for this gene.