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| Cat.No | ACP14168 | Target Name | ST8SIA1 |
|---|---|---|---|
| Target Synonyms | 8 polysialyltransferase; GD3S; SIA8A_HUMAN; Sialyltransferase 8 (alpha N acetylneuraminate: alpha 2, 8 sialyltransferase, 8 sialyltransferase 1; ST8 alpha N acetyl neuraminide alpha 28 sialyltransferase 1; ST8Sia I; ST8SIA1; ST8SiaI, 8 sialyltransferase 8A; Alpha N acetylneuraminide alpha 2, 8 sialyltransferase; Alpha-2; Alpha-N-acetylneuraminide alpha-2; Disialoganglioside (GD3) synthase; Ganglioside GD3 synthase; Ganglioside GT3 synthase; Ganglioside specific alpha 2, 8 sialytransferase, 8-sialyltransferase 8A; 8-sialyltransferase; Alpha 2, GD3 synthase) A; Sialyltransferase 8A (alpha N acetylneuraminate: alpha 2, GD3 synthase); Sialyltransferase 8A; Sialytransferase St8Sia I; SIAT8; SIAT8-A; SIAT8A; ST8 alpha N acetyl neuraminide alpha 2 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q92185 |
|---|
Uniprot Id
Q92185
Target Species
Human
Target Name
ST8SIA1
Target Full Name
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase
Target Function
Catalyzes the addition of sialic acid in alpha 2,8-linkage to the sialic acid moiety of the ganglioside GM3 to form ganglioside GD3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid. Can catalyze the addition of a second alpha-2,8-sialic acid to GD3 to form GT3. Can use GM1b, GD1a and GT1b as acceptor substrates to synthesize GD1c, GT1a and GQ1b respectively. Can synthesize unusual tetra- and pentasialylated lactosylceramide derivatives identified as GQ3 (II3Neu5Ac4-Gg2Cer) and GP3 (II3Neu5Ac5-Gg2Cer) in breast cancer cells.
Target Subcellular Location
Golgi apparatus membrane; Single-pass type II membrane protein.
Target Protein Families
Glycosyltransferase 29 family
Target Tissue Specificity
Strongly expressed in melanoma cell lines, adult and fetal brain and to a lesser extent in adult and fetal lung.
Target Synonyms
8-sialyltransferase 8A; 8-sialyltransferase; Alpha 2,8 sialyltransferase 8A; Alpha N acetylneuraminide alpha 2,8 sialyltransferase; Alpha-2; Alpha-N-acetylneuraminide alpha-2; Disialoganglioside (GD3) synthase; Ganglioside GD3 synthase; Ganglioside GT3 synthase; Ganglioside specific alpha 2,8 polysialyltransferase; GD3S; SIA8A_HUMAN; Sialyltransferase 8 (alpha N acetylneuraminate: alpha 2,8 sialytransferase, GD3 synthase) A; Sialyltransferase 8A (alpha N acetylneuraminate: alpha 2,8 sialyltransferase, GD3 synthase); Sialyltransferase 8A; Sialytransferase St8Sia I; SIAT8; SIAT8-A; SIAT8A; ST8 alpha N acetyl neuraminide alpha 2,8 sialyltransferase 1; ST8 alpha N acetyl neuraminide alpha 28 sialyltransferase 1; ST8Sia I; ST8SIA1; ST8SiaI
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