Recombinant Human Ankyrin repeat and SOCS box protein 7 (ASB7)

Uniprot Id

Q9H672

Target Species

Human

Target Name

ASB7

Target Full Name

Ankyrin repeat and SOCS box protein 7

Target Function

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Target Protein Families

Ankyrin SOCS box (ASB) family

Target Synonyms

ASB7Ankyrin repeat and SOCS box protein 7; ASB-7

Target Background

The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described.