Recombinant Human AP-3 complex subunit sigma-2 (AP3S2)

Uniprot Id

P59780

Target Species

Human

Target Name

AP3S2

Target Full Name

AP-3 complex subunit sigma-2

Target Function

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

Target Subcellular Location

Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.

Target Protein Families

Adaptor complexes small subunit family

Target Tissue Specificity

Present in all adult tissues examined.

Target Synonyms

Adapter related protein complex 3 sigma 2 subunit; Adapter-related protein complex 3 sigma-2 subunit; AP 3 complex sigma 3B subunit; AP-3 complex subunit sigma-2; AP-3 complex subunit sigma-3B; Ap3s2; AP3S2_HUMAN; Clathrin adaptor complex AP3 sigma 3b subunit; Clathrin associated/assembly/adaptor protein; small 4 22-kD; Sigma 3B adaptin; Sigma adaptin 3b; Sigma-3B-adaptin; Sigma-adaptin 3b; Sigma3B-adaptin

Target Background

Predicted to be involved in anterograde synaptic vesicle transport and vesicle-mediated transport. Located in intracellular membrane-bounded organelle. Part of AP-3 adaptor complex.