Recombinant Human AP-4 complex subunit epsilon-1 (AP4E1), Truncated

Uniprot Id

Q9UPM8

Target Species

Human

Target Name

AP4E1

Target Full Name

AP-4 complex subunit epsilon-1

Target Function

Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable)

Target Involvement

Spastic paraplegia 51, autosomal recessive (SPG51); Stuttering, familial persistent 1 (STUT1)

Target Subcellular Location

Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.

Target Protein Families

Adaptor complexes large subunit family

Target Tissue Specificity

Widely expressed.

Target Synonyms

AP4E1AP-4 complex subunit epsilon-1; AP-4 adaptor complex subunit epsilon; Adaptor-related protein complex 4 subunit epsilon-1; Epsilon subunit of AP-4; Epsilon-adaptin