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| Cat.No | ACP13100 | Target Name | AMER2 |
|---|---|---|---|
| Target Synonyms | AMER2; FAM123AAPC membrane recruitment protein 2; Amer2; Protein FAM123A | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-671 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8N7J2 |
|---|
Uniprot Id
Q8N7J2
Target Species
Human
Target Name
AMER2
Target Full Name
APC membrane recruitment protein 2
Target Function
Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex.
Target Subcellular Location
Cell membrane; Peripheral membrane protein. Note=Translocates to the cell membrane following binding to PtdIns(4,5)P2.
Target Protein Families
Amer family
Target Synonyms
AMER2; FAM123AAPC membrane recruitment protein 2; Amer2; Protein FAM123A
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