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Amino acids 220-269 constitute the expression domain of recombinant Human AQP1. The calculated molecular weight for this AQP1 protein is 21.6 kDa. Expression of this AQP1 protein is conducted in e.coli. The N-terminal 6xHis-SUMO tag was fused into the coding gene segment of AQP1, making it easier to detect and purify the AQP1 recombinant protein in the later stages of expression and purification.Aquaporin-1 (AQP1) is a transmembrane water channel protein widely distributed in various cell types. Within organisms, AQP1 plays a crucial role in the transport of water and solutes. Especially in the kidneys, lungs, and vascular system, AQP1 is essential for maintaining water balance and regulating fluid content. Studies indicate that AQP1 plays a certain regulatory role in tumor angiogenesis, making it a hot topic in cancer research. Additionally, AQP1 is closely associated with the development of some inflammatory and neurological disorders. In neurobiology research, the expression of AQP1 in neurons is linked to both water balance and neural signal transmission.
Amino acids 220-269 constitute the expression domain of recombinant Human AQP1. The calculated molecular weight for this AQP1 protein is 21.6 kDa. Expression of this AQP1 protein is conducted in e.coli. The N-terminal 6xHis-SUMO tag was fused into the coding gene segment of AQP1, making it easier to detect and purify the AQP1 recombinant protein in the later stages of expression and purification.Aquaporin-1 (AQP1) is a transmembrane water channel protein widely distributed in various cell types. Within organisms, AQP1 plays a crucial role in the transport of water and solutes. Especially in the kidneys, lungs, and vascular system, AQP1 is essential for maintaining water balance and regulating fluid content. Studies indicate that AQP1 plays a certain regulatory role in tumor angiogenesis, making it a hot topic in cancer research. Additionally, AQP1 is closely associated with the development of some inflammatory and neurological disorders. In neurobiology research, the expression of AQP1 in neurons is linked to both water balance and neural signal transmission.
| Cat.No | ACP02516 | Target Name | AQP1 |
|---|---|---|---|
| Target Synonyms | AQP1; CHIP28; Aquaporin-1; AQP-1; Aquaporin-CHIP; Urine water channel; Water channel protein for red blood cells and kidney proximal tubule | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 220-269aa |
| Mol Weight | 21.6kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P29972 |
|---|
Uniprot Id
P29972
Target Species
Human
Target Name
AQP1
Target Full Name
Aquaporin-1
Target Function
Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
Target Subcellular Location
Cell membrane; Multi-pass membrane protein.
Target Protein Families
MIP/aquaporin (TC 1.A.8) family
Target Tissue Specificity
Detected in erythrocytes (at protein level). Expressed in a number of tissues including erythrocytes, renal tubules, retinal pigment epithelium, heart, lung, skeletal muscle, kidney and pancreas. Weakly expressed in brain, placenta and liver.
Target Research Area
Transport
Target Synonyms
AQP1; CHIP28; Aquaporin-1; AQP-1; Aquaporin-CHIP; Urine water channel; Water channel protein for red blood cells and kidney proximal tubule
Target Background
This gene encodes a small integral membrane protein with six bilayer spanning domains that functions as a water channel protein. This protein permits passive transport of water along an osmotic gradient. This gene is a possible candidate for disorders involving imbalance in ocular fluid movement.
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