Recombinant Human Aspartate–tRNA ligase, cytoplasmic (DARS)

Uniprot Id

P14868

Target Species

Human

Target Name

DARS1

Target Full Name

Aspartate--tRNA ligase, cytoplasmic

Target Function

Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.

Target Involvement

Hypomyelination with brainstem and spinal cord involvement and leg spasticity (HBSL)

Target Subcellular Location

Cytoplasm, cytosol.

Target Protein Families

Class-II aminoacyl-tRNA synthetase family, Type 2 subfamily

Target Tissue Specificity

Expression in the developing and adult brain shows similar patterns. Highly expressed in the ventricular and subventricular zones, including hippocampal subfields, the midlateral temporal cortex and the frontal polar cortex. The cerebellum, cerebral corte

Target Synonyms

Aspartate tRNA ligase 1 cytoplasmic; Aspartate tRNA ligase; Aspartate--tRNA ligase; Aspartyl tRNA synthetase; Aspartyl tRNA synthetase cytoplasmic; Aspartyl-tRNA synthetase; AspRS; Cell proliferation inducing gene 40 protein; Cell proliferation inducing protein 40; Cell proliferation-inducing gene 40 protein; cytoplasmic; Dars; DKFZp781B11202; MGC111579; SYDC_HUMAN

Target Background

This gene encodes a member of a multienzyme complex that functions in mediating the attachment of amino acids to their cognate tRNAs. The encoded protein ligates L-aspartate to tRNA(Asp). Mutations in this gene have been found in patients showing hypomyelination with brainstem and spinal cord involvement and leg spasticity. Alternative splicing results in multiple transcript variants.