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| Cat.No | ACP00564 | Target Name | RECQL5 |
|---|---|---|---|
| Target Synonyms | DNA helicase, RecQ-like type 5;RecQ5;RecQ protein-like 5 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 39-213aa |
| Mol Weight | 26.1 kDa | Protein Length | Partial |
| Purity | Greater than 95% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O94762 |
|---|
Uniprot Id
O94762
Target Species
Human
Target Name
RECQL5
Target Full Name
ATP-dependent DNA helicase Q5
Target Function
Isoform beta is a DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination.
Target Subcellular Location
[Isoform Beta]: Nucleus, nucleoplasm.; [Isoform Alpha]: Cytoplasm.; [Isoform Gamma]: Cytoplasm.
Target Protein Families
Helicase family, RecQ subfamily
Target Tissue Specificity
Ubiquitous.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
ATP-dependent DNA helicase Q5; DNA helicase; DNA helicase; RecQ like type 5; DNA helicase; RECQ-like; type 5; EC 3.6.1.-; FLJ90603; RecQ helicase protein-like 5 beta ; RecQ protein-like 5; RecQ protein-like 5; isoform CRA_b; RecQ-like type 5; RecQ5; RECQ5_HUMAN; Recq5b; RECQL5; Recql5b
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