Recombinant Human ATP-dependent RNA helicase DDX3Y (DDX3Y)

Cat.No	ACP21689	Target Name	DDX3Y
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	2-660	Protein Length	Full Length of Mature Protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP21689

Target Name

DDX3Y

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

2-660

Protein Length

Full Length of Mature Protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	O15523

Background Information

Uniprot Id

O15523
Target Species

Human
Target Name

DDX3Y
Target Full Name

ATP-dependent RNA helicase DDX3Y
Target Function

Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway.
Target Involvement

DDX3Y is located in the 'azoospermia factor a' (AZFa) region on chromosome Y which is deleted in Sertoli cell-only syndrome. This is an infertility disorder in which no germ cells are visible in seminiferous tubules leading to azoospermia.
Target Subcellular Location

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm in an XPO1-dependent manner.
Target Protein Families

DEAD box helicase family, DDX3/DED1 subfamily
Target Tissue Specificity

Widely expressed at the mRNA level, with highest levels in testis. Testis-specific (at protein level). Expressed predominantly in spermatogonia, but occasionally detected in some pre-leptotene/leptotene spermatocytes.
Target Synonyms

ATP dependent RNA helicase DDX3Y; ATP-dependent RNA helicase DDX3Y; DBY ; DDX3Y; DDX3Y_HUMAN; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3 Y linked ; DEAD box protein 3 Y chromosomal; DEAD box protein 3; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide Y chromosome; Y-chromosomal
Target Background

The protein encoded by this gene is a member of the DEAD-box RNA helicase family, characterized by nine conserved motifs, included the conserved Asp-Glu-Ala-Asp (DEAD) motif. These motifs are thought to be involved in ATP binding, hydrolysis, RNA binding, and in the formation of intramolecular interactions. This protein shares high similarity to DDX3X, on the X chromosome, but a deletion of this gene is not complemented by DDX3X. Mutations in this gene result in male infertility, a reduction in germ cell numbers, and can result in Sertoli-cell only sydrome. Pseudogenes sharing similarity to both this gene and the DDX3X paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Recombinant Human ATP-dependent RNA helicase DDX3Y (DDX3Y)

Specifications

Immunogen Information

Inquire Recombinant Human ATP-dependent RNA helicase DDX3Y (DDX3Y) Now

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