Recombinant Human ATP-dependent RNA helicase DHX29 (DHX29), Truncated

Uniprot Id

Q7Z478

Target Species

Human

Target Name

DHX29

Target Full Name

ATP-dependent RNA helicase DHX29

Target Function

ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.

Target Subcellular Location

Cytoplasm.

Target Protein Families

DEAD box helicase family, DEAH subfamily

Target Synonyms

DHX29; DDX29ATP-dependent RNA helicase DHX29; EC 3.6.4.13; DEAH box protein 29; Nucleic acid helicase DDXx

Target Background

This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein functions in translation initiation, and is specifically required for ribosomal scanning across stable mRNA secondary structures during initiation codon selection. This protein may also play a role in sensing virally derived cytosolic nucleic acids. Knockdown of this gene results in reduced protein translation and impaired proliferation of cancer cells.