Recombinant Human ATP-dependent translocase ABCB1 (ABCB1), Truncated

Cat.No	ACP01666	Target Name	ABCB1
Target Synonyms	(ATP-binding cassette sub-family B member 1)(Multidrug resistance protein 1)(P-glycoprotein 1)(Phospholipid transporter ABCB1)(CD antigen CD243)	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	350-710aa
Mol Weight	44.2 kDa	Protein Length	Partial
Purity	Greater than 85% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP01666

Target Name

ABCB1

Target Synonyms

(ATP-binding cassette sub-family B member 1)(Multidrug resistance protein 1)(P-glycoprotein 1)(Phospholipid transporter ABCB1)(CD antigen CD243)

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

350-710aa

Mol Weight

44.2 kDa

Protein Length

Partial

Purity

Greater than 85% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P08183

Background Information

Uniprot Id

P08183
Target Species

Human
Target Name

ABCB1
Target Full Name

ATP-dependent translocase ABCB1
Target Function

Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Target Involvement

Inflammatory bowel disease 13 (IBD13)
Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Apical cell membrane.
Target Protein Families

ABC transporter superfamily, ABCB family, Multidrug resistance exporter (TC 3.A.1.201) subfamily
Target Tissue Specificity

Expressed in liver, kidney, small intestine and brain.
Target Research Area

Transport
Target Synonyms

ABC20; ABCB1; ATP binding cassette, sub family B (MDR/TAP), member 1; ATP-binding cassette sub-family B member 1; CD243; CLCS; Colchicin sensitivity; Doxorubicin resistance; GP170; MDR1; MDR1_HUMAN; Multidrug resistance 1; Multidrug resistance protein 1; P glycoprotein 1; P gp; P-glycoprotein 1; PGY1
Target Background

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants.

Recombinant Human ATP-dependent translocase ABCB1 (ABCB1), Truncated

Specifications

Immunogen Information

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