Recombinant Human ATPase family AAA domain-containing protein 3B (ATAD3B), Truncated

Uniprot Id

Q5T9A4

Target Species

Human

Target Name

ATAD3B

Target Full Name

ATPase family AAA domain-containing protein 3B

Target Function

May play a role in a mitochondrial network organization typical for stem cells, characterized by reduced mitochondrial metabolism, low mtDNA copies and fragmentated mitochondrial network. may act by suppressing ATAD3A function, interfering with ATAD3A interaction with matrix nucleoid complexes.

Target Subcellular Location

Mitochondrion inner membrane; Peripheral membrane protein.

Target Protein Families

AAA ATPase family

Target Tissue Specificity

Tends to be down-regulated in differentiated cells and re-expressed in pluripotent stem cells or cancer cells (at protein level).

Target Synonyms

ATAD3B; KIAA1273; TOB3; ATPase family AAA domain-containing protein 3B; AAA-TOB3

Target Background

The protein encoded by this gene is localized to the mitochondrial inner membrane, where it can bind to a highly-related protein, ATAD3A. ATAD3A appears to interact with matrix nucleoid complexes, and the encoded protein negatively regulates that interaction. This gene is expressed almost exclusively in pluripotent embryonic stem cells and some cancer cells. Two transcript variants encoding different isoforms have been found for this gene.