Recombinant Human Atrial natriuretic peptide-converting enzyme (CORIN), Truncated

Uniprot Id

Q9Y5Q5

Target Species

Human

Target Name

CORIN

Target Full Name

Atrial natriuretic peptide-converting enzyme

Target Function

Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) and brain natriuretic peptide (NPPB) processing. Converts through proteolytic cleavage the non-functional propeptides NPPA and NPPB into their active hormones, ANP and BNP(1-32) respectively, thereby regulating blood pressure in the heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney.; has weaker endopeptidase activity compared to isoform 1.

Target Involvement

Pre-eclampsia/eclampsia 5 (PEE5)

Target Subcellular Location

Cell membrane; Single-pass type II membrane protein. Note=May easily detached from the endothelial cell membrane.; [Isoform 2]: Cell membrane; Single-pass type II membrane protein. Note=Less efficiently targeted to the cell membrane compared to isoform 1.; [Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment]: Secreted. Note=Soluble form produced following cleavage by ADAM10.; [Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment]: Secreted. Note=Soluble form produced following autocatalytic cleavage.; [Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment]: Secreted. Note=Soluble form produced following autocatalytic cleavage.

Target Protein Families

Peptidase S1 family

Target Tissue Specificity

Highly expressed in heart. Expressed in heart myocytes. Also expressed in pregnant uterus. Detected in blood, in plasma as well as in serum (at protein level).

Target Research Area

Cardiovascular

Target Synonyms

activated protease fragment; ATC 2; ATC2; Atrial natriuretic peptide-converting enzyme; Atrial natriuteric peptide converting enzyme; Corin; Corin serine peptidase; CORIN_HUMAN; CRN; Heart specific serine proteinase; Heart specific serine proteinase ATC2; Heart-specific serine proteinase ATC2; MGC119742; Pro ANP convertase; Pro ANP converting enzyme; Pro-ANP-converting enzyme; TMPRSS 10; TMPRSS10; Transmembrane protease serine 10

Target Background

This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.