Recombinant Human Axin-2 (AXIN2), Truncated

Uniprot Id

Q9Y2T1

Target Species

Human

Target Name

AXIN2

Target Full Name

Axin-2

Target Function

Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.

Target Involvement

Colorectal cancer (CRC); Oligodontia-colorectal cancer syndrome (ODCRCS)

Target Subcellular Location

Cytoplasm.

Target Tissue Specificity

Expressed in brain and lymphoblast.

Target Research Area

Cancer

Target Synonyms

Axil; Axin like protein; Axin-2; Axin-like protein; Axin2; AXIN2_HUMAN; Axis inhibition protein 2; Conductin; DKFZp781B0869; MGC10366; MGC126582

Target Background

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.