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| Cat.No | ACP06966 | Target Name | BDKRB1 |
|---|---|---|---|
| Target Synonyms | BDKRB1; BRADYB1; B1 bradykinin receptor; B1R; BK-1 receptor | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P46663 |
|---|
Uniprot Id
P46663
Target Species
Human
Target Name
BDKRB1
Target Full Name
B1 bradykinin receptor
Target Function
This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.
Target Subcellular Location
Cell membrane; Multi-pass membrane protein.
Target Protein Families
G-protein coupled receptor 1 family, Bradykinin receptor subfamily, BDKRB1 sub-subfamily
Target Synonyms
BDKRB1; BRADYB1; B1 bradykinin receptor; B1R; BK-1 receptor
Target Background
Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. The protein encoded by this gene belongs to the G-protein coupled receptor 1 family. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses.
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