Recombinant Human Breast cancer metastasis-suppressor 1 (BRMS1), Truncated

Uniprot Id

Q9HCU9

Target Species

Human

Target Name

BRMS1

Target Full Name

Breast cancer metastasis-suppressor 1

Target Function

Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.

Target Subcellular Location

Nucleus. Cytoplasm. Note=Predominantly nuclear.

Target Protein Families

BRMS1 family

Target Tissue Specificity

Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies.

Target Research Area

Apoptosis

Target Synonyms

AV003220; AW554636; Breast cancer metastasis suppressor 1; Breast cancer metastasis-suppressor 1; BRMS1; BRMS1_HUMAN; DKFZp564A063 ; MGC95128

Target Background

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.