Recombinant Human Bromodomain-containing protein 1 (BRD1), Truncated

Uniprot Id

O95696

Target Species

Human

Target Name

BRD1

Target Full Name

Bromodomain-containing protein 1

Target Function

Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation.

Target Subcellular Location

Nucleus. Chromosome.

Target Tissue Specificity

Highly expressed in testis.

Target Synonyms

BR140-like protein; BRD1; BRD1_HUMAN; BRL; Bromodomain and PHD finger-containing protein 2; Bromodomain containing 1; Bromodomain-containing protein 1; BRPF1; BRPF2; DKFZp686F0325

Target Background

This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schizophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants.