Recombinant Human C-terminal-binding protein 1 (CTBP1)

Uniprot Id

Q13363

Target Species

Human

Target Name

CTBP1

Target Full Name

C-terminal-binding protein 1

Target Function

Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.

Target Subcellular Location

Cytoplasm. Nucleus.

Target Protein Families

D-isomer specific 2-hydroxyacid dehydrogenase family

Target Tissue Specificity

Expressed in germinal center B-cells.

Target Synonyms

BARS; brefeldin A- ribosylated substrate; C terminal binding protein 1; C-terminal-binding protein 1; CTBP; CtBP1; CTBP1_HUMAN; MGC104684

Target Background

This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.