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The recombinant Human CLEC18A was expressed with the amino acid range of 27-446. The theoretical molecular weight of the CLEC18A protein is 62.9 kDa. This CLEC18A recombinant protein is manufactured in e.coli. The CLEC18A gene fragment has been modified by fusing the N-terminal 6xHis-SUMO tag, providing convenience in detecting and purifying the recombinant CLEC18A protein during the following stages.Human C-type lectin domain family 18 member A (CLEC18A) is a secretory protein that is most highly expressed in human myeloid cells and the liver. Studies have shown that CLEC18A functions as a TLR3 coreceptor, suggesting its potential role in enhancing host immune responses to viral infections. There is evidence indicating that plasma CLEC18A levels exhibit a correlation with the stage of HBV infection, suggesting its potential utility as a biomarker for predicting patient outcomes. Studies have revealed a significant association between CLEC18A and HCV infection, particularly in cases of HCV-associated mixed cryoglobulinemia (MC).
The recombinant Human CLEC18A was expressed with the amino acid range of 27-446. The theoretical molecular weight of the CLEC18A protein is 62.9 kDa. This CLEC18A recombinant protein is manufactured in e.coli. The CLEC18A gene fragment has been modified by fusing the N-terminal 6xHis-SUMO tag, providing convenience in detecting and purifying the recombinant CLEC18A protein during the following stages.Human C-type lectin domain family 18 member A (CLEC18A) is a secretory protein that is most highly expressed in human myeloid cells and the liver. Studies have shown that CLEC18A functions as a TLR3 coreceptor, suggesting its potential role in enhancing host immune responses to viral infections. There is evidence indicating that plasma CLEC18A levels exhibit a correlation with the stage of HBV infection, suggesting its potential utility as a biomarker for predicting patient outcomes. Studies have revealed a significant association between CLEC18A and HCV infection, particularly in cases of HCV-associated mixed cryoglobulinemia (MC).
| Cat.No | ACP04185 | Target Name | CLEC18A |
|---|---|---|---|
| Target Synonyms | C-type lectin domain family 18 member A; CL18A_HUMAN; CLEC18A; FLJ77955; Mannose receptor-like protein 2; MGC164804; Mrcl; MRCL1; MRLP2 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 27-446aa |
| Mol Weight | 62.9kDa | Protein Length | Full Length of Mature Protein |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | A5D8T8 |
|---|
Uniprot Id
A5D8T8
Target Species
Human
Target Name
CLEC18A
Target Full Name
C-type lectin domain family 18 member A
Target Function
Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans.
Target Subcellular Location
Secreted. Endoplasmic reticulum. Golgi apparatus. Endosome.
Target Tissue Specificity
Dectected in all cell lines tested and in peripheral blood cells.
Target Research Area
Others
Target Synonyms
C-type lectin domain family 18 member A; CL18A_HUMAN; CLEC18A; FLJ77955; Mannose receptor-like protein 2; MGC164804; Mrcl; MRCL1; MRLP2
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