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Recombinant Human C2 domain-containing protein 3 (C2CD3), Truncated

ACP17443

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Specifications

Cat.No	ACP17443	Target Name	C2CD3
Target Synonyms	C2CD3; C2 domain-containing protein 3	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q4AC94

Background Information

Uniprot Id

Q4AC94
Target Species

Human
Target Name

C2CD3
Target Full Name

C2 domain-containing protein 3
Target Function

Component of the centrioles that acts as a positive regulator of centriole elongation. Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation. Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3.
Target Involvement

Orofaciodigital syndrome 14 (OFD14)
Target Subcellular Location

Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to centrioles and procentrioles both in interphase and mitosis. Localizes to centriolar satellites, localization is dependent on PCM1 and dynein-mediated retrograde transport. Also localizes to the distal ends of the mother and daughter centrioles.
Target Synonyms

C2CD3; C2 domain-containing protein 3

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Recombinant Human C2 domain-containing protein 3 (C2CD3), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human C2 domain-containing protein 3 (C2CD3), Truncated Now

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