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| Cat.No | ACP19751 | Target Name | CHP2 |
|---|---|---|---|
| Target Synonyms | CHP2; HCA520Calcineurin B homologous protein 2; Hepatocellular carcinoma-associated antigen 520 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 2-196 |
| Protein Length | Full Length of Mature Protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O43745 |
|---|
Uniprot Id
O43745
Target Species
Human
Target Name
CHP2
Target Full Name
Calcineurin B homologous protein 2
Target Function
Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.
Target Subcellular Location
Nucleus. Cytoplasm. Cell membrane.
Target Protein Families
Calcineurin regulatory subunit family, CHP subfamily
Target Tissue Specificity
Expressed in malignantly transformed cells but not detected in normal tissues.
Target Synonyms
CHP2; HCA520Calcineurin B homologous protein 2; Hepatocellular carcinoma-associated antigen 520
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