Recombinant Human Calpain-5 (CAPN5)

Uniprot Id

O15484

Target Species

Human

Target Name

CAPN5

Target Full Name

Calpain-5

Target Function

Calcium-regulated non-lysosomal thiol-protease.

Target Involvement

Vitreoretinopathy, neovascular inflammatory (VRNI)

Target Protein Families

Peptidase C2 family

Target Tissue Specificity

Expressed in many tissues. Strong expression in the photoreceptor cells of the retina, with a punctate pattern of labeling over the nuclei and inner segments with less expression along the other segments and outer plexiform layer.

Target Synonyms

ADNIV; Calpain htra 3; Calpain htra-3; Calpain-5; CAN5_HUMAN; CAPN 5; Capn5; nCL 3; nCL-3; New calpain 3; VRNI

Target Background

Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3.