Recombinant Human Calsequestrin-1 (CASQ1)

Cat.No	ACP23257	Target Name	CASQ1
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	35-396	Protein Length	Full Length of Mature Protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP23257

Target Name

CASQ1

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

35-396

Protein Length

Full Length of Mature Protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P31415

Background Information

Uniprot Id

P31415
Target Species

Human
Target Name

CASQ1
Target Full Name

Calsequestrin-1
Target Function

Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity.
Target Involvement

Myopathy, vacuolar, with CASQ1 aggregates (VMCQA); Myopathy, tubular aggregate, 1 (TAM1)
Target Subcellular Location

Endoplasmic reticulum. Sarcoplasmic reticulum. Sarcoplasmic reticulum lumen. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Mitochondrion matrix.
Target Protein Families

Calsequestrin family
Target Tissue Specificity

Expressed in myoblasts (at protein level).
Target Synonyms

Calmitin; Calmitine; Calsequestrin 1 (fast twitch; skeletal muscle); Calsequestrin; Calsequestrin; cell; Calsequestrin; skeletal muscle isoform; Calsequestrin-1; CASQ; Casq1; CASQ1_HUMAN; PDIB1; skeletal muscle isoform
Target Background

This gene encodes the skeletal muscle specific member of the calsequestrin protein family. Calsequestrin functions as a luminal sarcoplasmic reticulum calcium sensor in both cardiac and skeletal muscle cells. This protein, also known as calmitine, functions as a calcium regulator in the mitochondria of skeletal muscle. This protein is absent in patients with Duchenne and Becker types of muscular dystrophy.

Recombinant Human Calsequestrin-1 (CASQ1)

Specifications

Immunogen Information

Inquire Recombinant Human Calsequestrin-1 (CASQ1) Now

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