Recombinant Human cAMP-dependent protein kinase type I-beta regulatory subunit (PRKAR1B)

Uniprot Id

P31321

Target Species

Human

Target Name

PRKAR1B

Target Full Name

cAMP-dependent protein kinase type I-beta regulatory subunit

Target Function

Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.

Target Subcellular Location

Cell membrane.

Target Protein Families

CAMP-dependent kinase regulatory chain family

Target Tissue Specificity

Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.

Target Synonyms

cAMP dependent protein kinase type I beta regulatory subunit; cAMP-dependent protein kinase type I-beta regulatory subunit; KAP1_HUMAN; PKARI beta; PRKAR 1; PRKAR 1B; PRKAR1; Prkar1b; PRKAR1B protein; Protein kinase cAMP dependent regulatory type I beta; RIbeta

Target Background

The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene.