Recombinant Human Caseinolytic peptidase B protein homolog (CLPB)

Cat.No	ACP10686	Target Name	CLPB
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-707	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP10686

Target Name

CLPB

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-707

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9H078

Background Information

Uniprot Id

Q9H078
Target Species

Human
Target Name

CLPB
Target Full Name

Mitochondrial disaggregase
Target Function

May function as a regulatory ATPase and be related to secretion/protein trafficking process. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and proinflammatory cytokine IL6.
Target Involvement

3-methylglutaconic aciduria with cataracts, neurologic involvement and neutropenia (MEGCANN)
Target Subcellular Location

Mitochondrion intermembrane space.
Target Protein Families

ClpA/ClpB family
Target Tissue Specificity

Widely expressed (at protein level). Expressed in fetal, as well as in adult tissues, with highest levels in adult brain, including thalamus, hippocampus, occipital cortex and parietal cortex. Low expression in granulocytes.
Target Synonyms

Caseinolytic peptidase B; Caseinolytic peptidase B protein homolog; clpB; ClpB caseinolytic peptidase B homolog (E. coli); ClpB caseinolytic peptidase B homolog; CLPB_HUMAN; FLJ13152; HSP78; SKD3; Suppressor of potassium transport defect 3
Target Background

This gene belongs to the ATP-ases associated with diverse cellular activities (AAA+) superfamily. Members of this superfamily form ring-shaped homo-hexamers and have highly conserved ATPase domains that are involved in various processes including DNA replication, protein degradation and reactivation of misfolded proteins. All members of this family hydrolyze ATP through their AAA+ domains and use the energy generated through ATP hydrolysis to exert mechanical force on their substrates. In addition to an AAA+ domain, the protein encoded by this gene contains a C-terminal D2 domain, which is characteristic of the AAA+ subfamily of Caseinolytic peptidases to which this protein belongs. It cooperates with Hsp70 in the disaggregation of protein aggregates. Allelic variants of this gene are associated with 3-methylglutaconic aciduria, which causes cataracts and neutropenia. Alternative splicing results in multiple transcript variants.

Recombinant Human Caseinolytic peptidase B protein homolog (CLPB)

Specifications

Immunogen Information

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