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Our Recombinant Human CCN1 protein is designed to support your research in immunology. Representing the full length of the mature protein, this product is produced from the 25-381aa expression region of the human CCN1 gene, also known as CYR61, GIG1, and IGFBP10. Sourced from E.coli and featuring an N-terminal 6xHis-SUMO tag for efficient purification and detection, the Recombinant Human CCN1 protein is supplied as a lyophilized powder. With a purity of greater than 90% as determined by SDS-PAGE, our CCN1 protein ensures reliability and performance in your experiments.
Our Recombinant Human CCN1 protein is designed to support your research in immunology. Representing the full length of the mature protein, this product is produced from the 25-381aa expression region of the human CCN1 gene, also known as CYR61, GIG1, and IGFBP10.
Sourced from E.coli and featuring an N-terminal 6xHis-SUMO tag for efficient purification and detection, the Recombinant Human CCN1 protein is supplied as a lyophilized powder. With a purity of greater than 90% as determined by SDS-PAGE, our CCN1 protein ensures reliability and performance in your experiments.
| Cat.No | ACP02446 | Target Name | CYR61 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 25-381aa | Mol Weight | 55.4kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O00622 |
|---|
Uniprot Id
O00622
Target Species
Human
Target Name
CCN1
Target Full Name
CCN family member 1
Target Function
Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
Target Subcellular Location
Secreted.
Target Protein Families
CCN family
Target Research Area
Stem Cells
Target Synonyms
3CH61; CCN 1; CCN family member 1; CCN1; CYR 61; Cyr61; CYR61 protein; CYR61_HUMAN; Cysteine rich angiogenic inducer 61; Cysteine rich heparin binding protein 61; Cysteine-rich angiogenic inducer 61; GIG 1; GIG1; IBP-10; IGF-binding protein 10; Igfbp 10; IGFBP-10; Igfbp10; Insulin like growth factor binding protein 10; Insulin-like growth factor-binding protein 10; Protein CYR61; Protein GIG1
Target Background
The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation.
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