Recombinant Human Cell division cycle 7-related protein kinase (CDC7)

Uniprot Id

O00311

Target Species

Human

Target Name

CDC7

Target Full Name

Cell division cycle 7-related protein kinase

Target Function

Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylate MCM2 and MCM3.

Target Subcellular Location

Nucleus.

Target Protein Families

Protein kinase superfamily, Ser/Thr protein kinase family, CDC7 subfamily

Target Synonyms

Cdc 7; CDC7; CDC7 cell division cycle 7; CDC7 cell division cycle 7 like 1; Cdc7 Kinase; CDC7 L1; Cdc7 like 1; CDC7 related kinase; CDC7-related kinase; CDC7_HUMAN; CDC7L 1; CDC7L1; Cell division cycle 7 homolog; Cell division cycle 7 kinase; Cell division cycle 7 like protein 1; Cell division cycle 7 related protein kinase; Cell division cycle 7-related protein kinase; HsCDC 7; HsCdc7; Hsk 1; Hsk1; HuCDC 7; huCdc7; MGC117361; MGC126237; MGC126238

Target Background

This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected.