Recombinant Human Chloride intracellular channel protein 5 (CLIC5), Truncated

Uniprot Id

Q9NZA1

Target Species

Human

Target Name

CLIC5

Target Full Name

Chloride intracellular channel protein 5

Target Function

Required for normal hearing. It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti. Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture. Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens.

Target Involvement

Deafness, autosomal recessive, 103 (DFNB103)

Target Subcellular Location

[Isoform 1]: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Membrane; Single-pass membrane protein. Apical cell membrane; Single-pass membrane protein. Cytoplasm.; [Isoform 2]: Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Target Protein Families

Chloride channel CLIC family

Target Tissue Specificity

Widely expressed in both fetal and adult human tissues. Isoform 1 is expressed in renal glomeruli endothelial cells and podocytes (at protein level).

Target Synonyms

CLIC5; Chloride intracellular channel protein 5