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Recombinant Human Chromobox protein homolog 7 (CBX7)

Amino acids 1-251 form the expressed segment for recombinant Human CBX7. This CBX7 protein is theoretically predicted to have a molecular weight of 32.3 kDa. This CBX7 recombinant protein is manufactured in e.coli. The N-terminal 6xHis tag was fused into the coding gene segment of CBX7, making it easier to detect and purify the CBX7 recombinant protein in the later stages of expression and purification.Chromobox protein homolog 7 (CBX7) is a protein that regulates gene expression, with one of its most prominent research areas centered around its role in cancer development. The abnormal expression of CBX7 in various cancer types is associated with tumor growth, invasion, and metastasis. Researchers are endeavoring to unveil the molecular mechanisms of CBX7 in the initiation and progression of cancer, aiming to provide new targets for cancer treatment and prevention. Additionally, CBX7's research in stem cells and genomic stability is of great interest. CBX7 is involved in cell fate determination and the self-renewal processes of stem cells, influencing cellular functions under normal physiological conditions. Its regulatory role in the genome involves changes in chromatin structure, making it crucial for understanding cellular development and differentiation processes.

ACP04679

Amino acids 1-251 form the expressed segment for recombinant Human CBX7. This CBX7 protein is theoretically predicted to have a molecular weight of 32.3 kDa. This CBX7 recombinant protein is manufactured in e.coli. The N-terminal 6xHis tag was fused into the coding gene segment of CBX7, making it easier to detect and purify the CBX7 recombinant protein in the later stages of expression and purification.Chromobox protein homolog 7 (CBX7) is a protein that regulates gene expression, with one of its most prominent research areas centered around its role in cancer development. The abnormal expression of CBX7 in various cancer types is associated with tumor growth, invasion, and metastasis. Researchers are endeavoring to unveil the molecular mechanisms of CBX7 in the initiation and progression of cancer, aiming to provide new targets for cancer treatment and prevention. Additionally, CBX7’s research in stem cells and genomic stability is of great interest. CBX7 is involved in cell fate determination and the self-renewal processes of stem cells, influencing cellular functions under normal physiological conditions. Its regulatory role in the genome involves changes in chromatin structure, making it crucial for understanding cellular development and differentiation processes.

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Specifications


Cat.No ACP04679 Target NameCBX7
Target SynonymsCBX7; Chromobox protein homolog 7FormLiquid or Lyophilized powder
Expression SystemE.coliExpression Range1-251aa
Mol Weight32.3kDaProtein LengthFull length
PurityGreater than 90% as determined by SDS-PAGE.Storage Buffer5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information


Target SpeciesHumanUniprot IDO95931
Background Information
  • Uniprot Id

    O95931

  • Target Species

    Human

  • Target Name

    CBX7

  • Target Full Name

    Chromobox protein homolog 7

  • Target Function

    Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.

  • Target Subcellular Location

    Nucleus.

  • Target Research Area

    Transcription

  • Target Synonyms

    CBX7; Chromobox protein homolog 7

  • Target Background

    This gene encodes a protein that contains the CHROMO (CHRomatin Organization MOdifier) domain. The encoded protein is a component of the Polycomb repressive complex 1 (PRC1), and is thought to control the lifespan of several normal human cells.

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