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Amino acids 1-251 form the expressed segment for recombinant Human CBX7. This CBX7 protein is theoretically predicted to have a molecular weight of 32.3 kDa. This CBX7 recombinant protein is manufactured in e.coli. The N-terminal 6xHis tag was fused into the coding gene segment of CBX7, making it easier to detect and purify the CBX7 recombinant protein in the later stages of expression and purification.Chromobox protein homolog 7 (CBX7) is a protein that regulates gene expression, with one of its most prominent research areas centered around its role in cancer development. The abnormal expression of CBX7 in various cancer types is associated with tumor growth, invasion, and metastasis. Researchers are endeavoring to unveil the molecular mechanisms of CBX7 in the initiation and progression of cancer, aiming to provide new targets for cancer treatment and prevention. Additionally, CBX7's research in stem cells and genomic stability is of great interest. CBX7 is involved in cell fate determination and the self-renewal processes of stem cells, influencing cellular functions under normal physiological conditions. Its regulatory role in the genome involves changes in chromatin structure, making it crucial for understanding cellular development and differentiation processes.
Amino acids 1-251 form the expressed segment for recombinant Human CBX7. This CBX7 protein is theoretically predicted to have a molecular weight of 32.3 kDa. This CBX7 recombinant protein is manufactured in e.coli. The N-terminal 6xHis tag was fused into the coding gene segment of CBX7, making it easier to detect and purify the CBX7 recombinant protein in the later stages of expression and purification.Chromobox protein homolog 7 (CBX7) is a protein that regulates gene expression, with one of its most prominent research areas centered around its role in cancer development. The abnormal expression of CBX7 in various cancer types is associated with tumor growth, invasion, and metastasis. Researchers are endeavoring to unveil the molecular mechanisms of CBX7 in the initiation and progression of cancer, aiming to provide new targets for cancer treatment and prevention. Additionally, CBX7’s research in stem cells and genomic stability is of great interest. CBX7 is involved in cell fate determination and the self-renewal processes of stem cells, influencing cellular functions under normal physiological conditions. Its regulatory role in the genome involves changes in chromatin structure, making it crucial for understanding cellular development and differentiation processes.
| Cat.No | ACP04679 | Target Name | CBX7 |
|---|---|---|---|
| Target Synonyms | CBX7; Chromobox protein homolog 7 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-251aa |
| Mol Weight | 32.3kDa | Protein Length | Full length |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O95931 |
|---|
Uniprot Id
O95931
Target Species
Human
Target Name
CBX7
Target Full Name
Chromobox protein homolog 7
Target Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.
Target Subcellular Location
Nucleus.
Target Research Area
Transcription
Target Synonyms
CBX7; Chromobox protein homolog 7
Target Background
This gene encodes a protein that contains the CHROMO (CHRomatin Organization MOdifier) domain. The encoded protein is a component of the Polycomb repressive complex 1 (PRC1), and is thought to control the lifespan of several normal human cells.
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