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Recombinant Human Chromobox protein homolog 8 (CBX8)

ACP01932

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Specifications

Cat.No	ACP01932	Target Name	CBX8
Target Synonyms	(Polycomb 3 homolog)(Pc3)(hPc3)(Rectachrome 1)	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	1-389aa
Mol Weight	50.8 kDa	Protein Length	Full length
Purity	Greater than 85% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9HC52

Background Information

Uniprot Id

Q9HC52
Target Species

Human
Target Name

CBX8
Target Full Name

Chromobox protein homolog 8
Target Function

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Target Subcellular Location

Nucleus.
Target Research Area

Epigenetics and Nuclear Signaling
Target Synonyms

Cbx8; CBX8_HUMAN; Chromobox Homolog 8 (Drosophila Pc Class); Chromobox Homolog 8 (Pc Class Homolog; Drosophila); Chromobox Homolog 8; Chromobox protein homolog 8; hPc3; Pc Class 3 Homolog (Drosophila); Pc Class 3 Homolog; Pc3; Polycomb 3; Polycomb 3 homolog; RC1; Rectachrome 1
Target Background

Enables methylated histone binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in chromatin and nucleoplasm. Part of PRC1 complex. Biomarker of esophagus squamous cell carcinoma and glioblastoma.

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Recombinant Human Chromobox protein homolog 8 (CBX8)

Specifications

Immunogen Information

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