Recombinant Human Claudin-15 (CLDN15), Truncated

Uniprot Id

P56746

Target Species

Human

Target Name

CLDN15

Target Full Name

Claudin-15

Target Function

Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects against Cl(-) ions. Plays an important role in paracellular Na(+) transport in the intestine and in Na(+) homeostasis. Required for normal Na(+)-dependent intestinal nutrient uptake

Target Subcellular Location

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note=Tight junctions form continuous circumferential cell-cell contacts at the borders of apical and lateral cell membranes that seal the intercellular space and show up as strand-like structures in electron microscopy.

Target Protein Families

Claudin family

Target Tissue Specificity

Detected in colon (at protein level).

Target Synonyms

CLDN15; Claudin-15