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| Cat.No | ACP18580 | Target Name | ST3GAL1 |
|---|---|---|---|
| Target Synonyms | 3-GalNAc-alpha-2; 3-sialyltransferase 1; 3-sialyltransferase; 3-ST 1; Alpha 2; Alpha 23 ST; Beta galactoside alpha 23 sialyltransferase; Beta-galactoside alpha-2; beta-galactoside alpha-2 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q11201 |
|---|
Uniprot Id
Q11201
Target Species
Human
Target Name
ST3GAL1
Target Full Name
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
Target Function
A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids. Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage. Adds sialic acid to the core 1 O-glycan, Galbeta-(1->3)-GalNAc-O-Ser/Thr, which is a major structure of mucin-type O-glycans. As part of a homeostatic mechanism that regulates CD8-positive T cell numbers, sialylates core 1 O-glycans of T cell glycoproteins, SPN/CD43 and PTPRC/CD45. Prevents premature apoptosis of thymic CD8-positive T cells prior to peripheral emigration, whereas in the secondary lymphoid organs controls the survival of CD8-positive memory T cells generated following a successful immune response. Transfers sialic acid to asialofetuin, presumably onto Galbeta-(1->3)-GalNAc-O-Ser. Sialylates GM1a, GA1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively
Target Subcellular Location
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type II membrane protein. Secreted.
Target Protein Families
Glycosyltransferase 29 family
Target Tissue Specificity
Expressed in several tissues. Highest expression in lung, liver, skeletal muscle, kidney, pancreas, spleen and placenta.
Target Synonyms
3-GalNAc-alpha-2; 3-sialyltransferase 1; 3-sialyltransferase; 3-ST 1; Alpha 2; Alpha 23 ST; Beta galactoside alpha 23 sialyltransferase; Beta-galactoside alpha-2; beta-galactoside alpha-2,3-sialyltransferase 1; CMP N acetylneuraminate beta galactosamide alpha 23 sialyltransferase; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2; DKFZp666E036; DKFZp779K2051; FLJ36548; Gal beta 13 GalNAc alpha 23 sialyltransferase; Gal NAc6S; Gal-beta-1; Gal-NAc6S; MGC9183; OTTHUMP00000226912; OTTHUMP00000226913; SIA4A_HUMAN; Sialyltransferase 4A; SIAT4-A; SIAT4A; SIATFL; ST3Gal I; ST3GAL1; ST3GalA; ST3GalA.1; ST3GalI; ST3GalIA; ST3O
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