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The Recombinant Human F5 protein is a crucial tool for understanding coagulation processes and exploring potential therapeutic interventions in cardiovascular research. Coagulation factor V, also known as activated protein C cofactor, is an essential player in the blood clotting cascade, regulating the balance between procoagulant and anticoagulant activities. This product contains a partial sequence of the human F5 protein (1490-1614aa) expressed in E.coli, ensuring high-quality recombinant protein production. The N-terminal 6xHis-SUMO tag enables efficient purification and facilitates detection in downstream applications. With a purity greater than 90% as determined by SDS-PAGE, our Recombinant Human F5 protein provides a reliable reagent for your cardiovascular research needs. Supplied as a lyophilized powder, this product is readily reconstituted for immediate use in your experiments.
The Recombinant Human F5 protein is a crucial tool for understanding coagulation processes and exploring potential therapeutic interventions in cardiovascular research. Coagulation factor V, also known as activated protein C cofactor, is an essential player in the blood clotting cascade, regulating the balance between procoagulant and anticoagulant activities.
This product contains a partial sequence of the human F5 protein (1490-1614aa) expressed in E.coli, ensuring high-quality recombinant protein production. The N-terminal 6xHis-SUMO tag enables efficient purification and facilitates detection in downstream applications. With a purity greater than 90% as determined by SDS-PAGE, our Recombinant Human F5 protein provides a reliable reagent for your cardiovascular research needs. Supplied as a lyophilized powder, this product is readily reconstituted for immediate use in your experiments.
| Cat.No | ACP03663 | Target Name | F5 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1490-1614aa | Mol Weight | 30.4kDa |
| Protein Length | Partial | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P12259 |
|---|
Uniprot Id
P12259
Target Species
Human
Target Name
F5
Target Full Name
Coagulation factor V
Target Function
Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
Target Involvement
Factor V deficiency (FA5D); Thrombophilia due to activated protein C resistance (THPH2); Budd-Chiari syndrome (BDCHS); Ischemic stroke (ISCHSTR); Pregnancy loss, recurrent, 1 (RPRGL1)
Target Subcellular Location
Secreted.
Target Protein Families
Multicopper oxidase family
Target Tissue Specificity
Plasma.
Target Research Area
Cardiovascular
Target Synonyms
Activated protein C cofactor; APC cofactor; coagulation factor V (proaccelerin; labile factor); Coagulation factor V; coagulation factor V jinjiang A2 domain; Coagulation factor V light chain; F5; FA5_HUMAN; Factor V Leiden; FactorV; FVL; Labile factor; PCCF; Proaccelerin; proaccelerin; labile factor; Protein C cofactor; RPRGL1; THPH2
Target Background
This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance.
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