Recombinant Human Cocaine- and amphetamine-regulated transcript protein (CARTPT)

Uniprot Id

Q16568

Target Species

Human

Target Name

CARTPT

Target Full Name

Cocaine- and amphetamine-regulated transcript protein

Target Function

Satiety factor closely associated with the actions of leptin and neuropeptide Y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro.

Target Subcellular Location

Secreted.

Target Protein Families

CART family

Target Tissue Specificity

Hypothalamus. Found in neurons of the ventrolateral part of the arcuate nucleus, in the external zone of the median eminence, and also found in terminals in the periventricular part of the paraventricular nucleus.

Target Synonyms

CART; CART prepropeptide; CART(42-89); CART_HUMAN; Cartpt; Cocaine and amphetamine regulated transcript

Target Background

This gene encodes a preproprotein that is proteolytically processed to generate multiple biologically active peptides. These peptides play a role in appetite, energy balance, maintenance of body weight, reward and addiction, and the stress response. Expression of a similar gene transcript in rodents is upregulated following administration of cocaine and amphetamine. Mutations in this gene are associated with susceptibility to obesity in humans.