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| Cat.No | ACP11894 | Target Name | COL25A1 |
|---|---|---|---|
| Target Synonyms | COL25A1Collagen alpha-1(XXV) chain; Alzheimer disease amyloid-associated protein; AMY; CLAC-P) [Cleaved into: Collagen-like Alzheimer amyloid plaque component; CLAC)] | Form | Liquid or Lyophilized powder |
| Expression System | Yeast | Protein Length | Extracellular Domain |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9BXS0 |
|---|
Uniprot Id
Q9BXS0
Target Species
Human
Target Name
COL25A1
Target Full Name
Collagen alpha-1(XXV) chain
Target Function
Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.
Target Involvement
Fibrosis of extraocular muscles, congenital, 5 (CFEOM5)
Target Subcellular Location
Membrane; Single-pass type II membrane protein. Note=After proteolytic cleavage, CLAC is secreted.
Target Tissue Specificity
Expressed predominantly in brain. Deposited preferentially in primitive or neuritic amyloid plaques which are typical of Alzheimer disease.
Target Synonyms
COL25A1Collagen alpha-1(XXV) chain; Alzheimer disease amyloid-associated protein; AMY; CLAC-P) [Cleaved into: Collagen-like Alzheimer amyloid plaque component; CLAC)]
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