Recombinant Human Cullin-associated NEDD8-dissociated protein 1 (CAND1), Truncated

Cat.No	ACP15408	Target Name	CAND1
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP15408

Target Name

CAND1

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q86VP6

Background Information

Uniprot Id

Q86VP6
Target Species

Human
Target Name

CAND1
Target Full Name

Cullin-associated NEDD8-dissociated protein 1
Target Function

Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.
Target Subcellular Location

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.
Target Protein Families

CAND family
Target Synonyms

CAND 1; Cand1; CAND1_HUMAN; Cullin associated and neddylation dissociated 1; Cullin associated and neddylation dissociated protein 1; Cullin associated NEDD8 dissociated protein 1; Cullin-associated and neddylation-dissociated protein 1; Cullin-associated NEDD8-dissociated protein 1; DKFZP434M1414; FLJ10114; FLJ10929; FLJ38691; FLJ90441; KIAA0829; p120 CAND1; TATA binding protein interacting protein 120A; TBP interacting protein; TBP interacting protein of 120 kDa A; TBP Interacting Protein TIP120A; TBP-interacting protein 120A; TBP-interacting protein of 120 kDa A; TIP120; TIP120 protein; TIP120A
Target Background

This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalian cell culture, this protein predominantly localizes to the cytoplasm. Knockdown of this gene in preadipocytes results in blocked adipogenesis. Alternative splicing results in multiple transcript variants.

Recombinant Human Cullin-associated NEDD8-dissociated protein 1 (CAND1), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Cullin-associated NEDD8-dissociated protein 1 (CAND1), Truncated Now

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