Recombinant Human Cyclic nucleotide-gated cation channel beta-1 (CNGB1), Truncated

Uniprot Id

Q14028

Target Species

Human

Target Name

CNGB1

Target Full Name

Cyclic nucleotide-gated channel beta-1

Target Function

Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP.; Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties: it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit.

Target Involvement

Retinitis pigmentosa 45 (RP45)

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family, CNGB1 subfamily

Target Synonyms

CNGB1; CNCG2; CNCG3L; CNCG4; RCNC2Cyclic nucleotide-gated cation channel beta-1; Cyclic nucleotide-gated cation channel 4; CNG channel 4; CNG-4; CNG4; Cyclic nucleotide-gated cation channel gamma; Cyclic nucleotide-gated cation channel modulatory subunit; Cyclic nucleotide-gated channel beta-1; CNG channel beta-1; Glutamic acid-rich protein; GARP