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The recombinant Human CSTA was expressed with the amino acid range of 2-98. The expected molecular weight for the CSTA protein is calculated to be 38.3 kDa. This CSTA protein is produced using e.coli expression system. The CSTA coding gene included the N-terminal GST tag, which simplifies the detection and purification processes of the recombinant CSTA protein in following stages of expression and purification.Human cystatin-A (CSTA), also known as stefin A, is a member of the cystatin superfamily of cysteine proteinase inhibitors. CSTA plays a crucial role in regulating the activity of cysteine proteases by forming tight, reversible complexes with them. CSTA is primarily expressed in the epidermis, where it helps control the activity of proteases involved in skin homeostasis. Its inhibition of cathepsins protects against excessive protein degradation, contributing to the maintenance of skin integrity. Beyond its role in skin physiology, CSTA has been implicated in various pathological conditions, including cancer, where its dysregulation may influence tumor progression. Understanding CSTA's functions is vital for unraveling its diverse roles in health and disease.
The recombinant Human CSTA was expressed with the amino acid range of 2-98. The expected molecular weight for the CSTA protein is calculated to be 38.3 kDa. This CSTA protein is produced using e.coli expression system. The CSTA coding gene included the N-terminal GST tag, which simplifies the detection and purification processes of the recombinant CSTA protein in following stages of expression and purification.Human cystatin-A (CSTA), also known as stefin A, is a member of the cystatin superfamily of cysteine proteinase inhibitors. CSTA plays a crucial role in regulating the activity of cysteine proteases by forming tight, reversible complexes with them. CSTA is primarily expressed in the epidermis, where it helps control the activity of proteases involved in skin homeostasis. Its inhibition of cathepsins protects against excessive protein degradation, contributing to the maintenance of skin integrity. Beyond its role in skin physiology, CSTA has been implicated in various pathological conditions, including cancer, where its dysregulation may influence tumor progression. Understanding CSTA’s functions is vital for unraveling its diverse roles in health and disease.
| Cat.No | ACP01665 | Target Name | CSTA |
|---|---|---|---|
| Target Synonyms | (Cystatin-AS)(Stefin-A) | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 2-98aa |
| Mol Weight | 38.3 kDa | Protein Length | Full Length of Mature Protein |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P01040 |
|---|
Uniprot Id
P01040
Target Species
Human
Target Name
CSTA
Target Full Name
Cystatin-A
Target Function
This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis.
Target Involvement
Peeling skin syndrome 4 (PSS4)
Target Subcellular Location
Cytoplasm.
Target Protein Families
Cystatin family
Target Tissue Specificity
Expressed in the skin throughout the epidermis.
Target Research Area
Cancer
Target Synonyms
AREI; cstA; Cystatin A; Cystatin AS; Cystatin-A; Cystatin-AS; CYTA_HUMAN; Stefin A; Stefin-A; STF1; STFA
Target Background
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer.
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