Recombinant Human Cytokine-inducible SH2-containing protein (CISH)

Dive into signal transduction research with our premium Recombinant Human CISH protein, a vital component involved in cytokine signaling pathways. The cytokine-inducible SH2-containing protein (CISH) serves as a negative regulator of cytokine signaling, making it an essential player in immune responses and cellular homeostasis. This full-length Recombinant Human CISH protein is expressed in E. coli and encompasses the 1-258aa expression region. The N-terminal GST-tag enables efficient protein purification and detection, contributing to a dependable product for your research endeavors. Boasting a purity greater than 90% as determined by SDS-PAGE, our Recombinant Human CISH protein ensures reliability and consistency in your signal transduction research. Available in lyophilized powder form, this protein can be conveniently incorporated into various experimental setups.

ACP03165

Dive into signal transduction research with our premium Recombinant Human CISH protein, a vital component involved in cytokine signaling pathways. The cytokine-inducible SH2-containing protein (CISH) serves as a negative regulator of cytokine signaling, making it an essential player in immune responses and cellular homeostasis.
This full-length Recombinant Human CISH protein is expressed in E. coli and encompasses the 1-258aa expression region. The N-terminal GST-tag enables efficient protein purification and detection, contributing to a dependable product for your research endeavors. Boasting a purity greater than 90% as determined by SDS-PAGE, our Recombinant Human CISH protein ensures reliability and consistency in your signal transduction research. Available in lyophilized powder form, this protein can be conveniently incorporated into various experimental setups.

Number

Cat.No	ACP03165	Target Name	CISH
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	1-258aa	Mol Weight	55.7kDa
Protein Length	Full length	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP03165

Target Name

CISH

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

1-258aa

Mol Weight

55.7kDa

Protein Length

Full length

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9NSE2

Background Information

Uniprot Id

Q9NSE2
Target Species

Human
Target Name

CISH
Target Full Name

Cytokine-inducible SH2-containing protein
Target Function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Target Tissue Specificity

Expressed in various epithelial tissues. Abundantly expressed in liver and kidney, and to a lesser extent in lung. The tissue distribution of isoforms 1 and 1B is distinct.
Target Research Area

Signal Transduction
Target Synonyms

BACTS2; cis 1; CIS; CIS-1; CIS1; Cish; CISH_HUMAN; Cytokine inducible inhibitor of signaling type 1B; Cytokine inducible SH2 containing protein; Cytokine-inducible SH2-containing protein; G18; Protein G18; SOCS; Suppressor of cytokine signaling
Target Background

The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.

Recombinant Human Cytokine-inducible SH2-containing protein (CISH)

Specifications

Immunogen Information

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