Recombinant Human D-amino-acid oxidase (DAO)

Uniprot Id

P14920

Target Species

Human

Target Name

DAO

Target Full Name

D-amino-acid oxidase

Target Function

Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.

Target Involvement

Schizophrenia (SCZD)

Target Subcellular Location

Peroxisome.

Target Protein Families

DAMOX/DASOX family

Target Research Area

Metabolism

Target Synonyms

D-amino-acid oxidase; DAAO; DAMOX; DAO; DAO1; EC 1.4.3.3; MGC35381; OXDA; OXDA_HUMAN

Target Background

This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia.