Recombinant Human Deoxyguanosine kinase, mitochondrial (DGUOK)

Uniprot Id

Q16854

Target Species

Human

Target Name

DGUOK

Target Full Name

Deoxyguanosine kinase, mitochondrial

Target Function

Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs. Widely used as target of antiviral and chemotherapeutic agents.

Target Involvement

Mitochondrial DNA depletion syndrome 3 (MTDPS3); Portal hypertension, non-cirrhotic (NCPH); Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 4 (PEOB4)

Target Subcellular Location

Mitochondrion.

Target Protein Families

DCK/DGK family

Target Tissue Specificity

Ubiquitous. Highest expression in muscle, brain, liver and lymphoid tissues.

Target Research Area

Signal Transduction

Target Synonyms

DGUOK; DGK; Deoxyguanosine kinase; mitochondrial; dGK; EC 2.7.1.113

Target Background

In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene.