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Recombinant Human Derlin-3 (DERL3), Truncated

ACP07921

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Specifications

Cat.No	ACP07921	Target Name	DERL3
Target Synonyms	DERL3; C22orf14; DER3; LLN2; Derlin-3; Degradation in endoplasmic reticulum protein 3; DERtrin-3; Der1-like protein 3	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q96Q80

Background Information

Uniprot Id

Q96Q80
Target Species

Human
Target Name

DERL3
Target Full Name

Derlin-3
Target Function

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded glycoproteins. May be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation
Target Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.
Target Protein Families

Derlin family
Target Tissue Specificity

Unlike DERL1 and DERL2, restricted to several tissues. Expressed at high levels in placenta, pancreas, spleen and small intestine.
Target Synonyms

DERL3; C22orf14; DER3; LLN2; Derlin-3; Degradation in endoplasmic reticulum protein 3; DERtrin-3; Der1-like protein 3

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Recombinant Human Derlin-3 (DERL3), Truncated

Specifications

Immunogen Information

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