Recombinant Human Deubiquitinating protein VCIP135 (VCPIP1), Truncated

Cat.No	ACP14080	Target Name	VCPIP1
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP14080

Target Name

VCPIP1

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q96JH7

Background Information

Uniprot Id

Q96JH7
Target Species

Human
Target Name

VCPIP1
Target Full Name

Deubiquitinating protein VCPIP1
Target Function

Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP. Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains.; (Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients.
Target Subcellular Location

Nucleus. Cytoplasm. Endoplasmic reticulum. Golgi apparatus, Golgi stack.
Target Synonyms

Deubiquitinating protein VCIP135; DUBA3; KIAA1850; Valosin containing protein (p97)/p47 complex interacting protein 1; Valosin containing protein p97/p47 complex interacting protein 1; Valosin containing protein p97/p47 complex interacting protein p135; Valosin-containing protein p97/p47 complex-interacting protein 1; Valosin-containing protein p97/p47 complex-interacting protein p135; VCIP1_HUMAN; VCIP135; VCP/p47 complex-interacting 135-kDa protein; Vcpip1
Target Background

Enables thiol-dependent deubiquitinase. Involved in protein deubiquitination; protein-DNA covalent cross-linking repair; and regulation of protein localization to chromatin. Located in cytoplasm and nucleus.

Recombinant Human Deubiquitinating protein VCIP135 (VCPIP1), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Deubiquitinating protein VCIP135 (VCPIP1), Truncated Now

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