Recombinant Human Dickkopf-related protein 4 (DKK4)

Uniprot Id

Q9UBT3

Target Species

Human

Target Name

DKK4

Target Full Name

Dickkopf-related protein 4

Target Function

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

Target Subcellular Location

Secreted.

Target Protein Families

Dickkopf family

Target Tissue Specificity

Expressed in cerebellum, T-cells, esophagus and lung.

Target Research Area

Immunology

Target Synonyms

Dickkopf 4; Dickkopf gene 4; Dickkopf homolog 4 (Xenopus laevis); Dickkopf homolog 4; Dickkopf related protein 4; Dickkopf-4; Dickkopf-related protein 4 short form; Dickkopf4; DKK 4; Dkk-4; DKK4; DKK4_HUMAN; hDkk 4; hDkk-4; hDkk4; MGC129562; MGC129563

Target Background

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2.